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Atopic Dermatitis
Genetic mutation in esophageal cancer found to have dual
effects
A genetic fault long believed to drive the
development of esophageal cancer may in fact play a protective role early in
the disease, according to new research published in Nature Cancer. This
unexpected discovery could help doctors identify which individuals are at
greater risk of developing cancer, potentially leading to more personalized and
effective preventive strategies.
"We often assume that mutations in
cancer genes are bad news, but that's not the whole story," says lead
researcher Francesca Ciccarelli, Professor of Cancer Genomics at Queen Mary
University of London's Barts Cancer Institute and Principal Group Leader at the
Francis Crick Institute, where the experimental work in this study took place.
"The context is crucial. These results support a paradigm shift in how we
think about the effect of mutations in cancer."
This research was funded by Cancer Research
UK and the experimental work in this study took place at the Francis Crick
Institute.
Just 12% of patients with esophageal cancer
in England survive their disease for 10 years or more. The UK has one of the
world's highest incidences of a subtype called esophageal adenocarcinoma, and
cases continue to increase. This cancer type develops from a condition called
Barrett's esophagus, in which the cells lining the esophagus become abnormal.
However, only around 1% of people with Barrett's go on to develop cancer each
year. In the new study, the research team sought to better understand why some cases
of Barrett's lead to cancer, while others do not, to support better prediction
and treatment of esophageal adenocarcinoma.
The team analyzed a large gene sequencing
dataset from more than 1,000 people with esophageal adenocarcinoma and more
than 350 people with Barrett's esophagus, including samples from the OCCAMS
consortium. They found that defects in a gene called CDKN2A were more common in
people with Barrett's esophagus who never progressed to cancer. This finding
was unexpected, as CDKN2A is commonly lost in various cancers and is well-known
as a tumor suppressor gene – a molecular safeguard that stops cancer from forming.
The research showed that if normal cells in
our esophagus lose CDKN2A, it helps promote the development of Barrett's
esophagus. However, it also protects cells against the loss of another key gene
encoding p53 – a critical tumor suppressor often dubbed the 'guardian of the
genome'. Loss of p53 strongly drives the progression of disease from Barrett's
to cancer.
The team found that potentially cancerous
cells that lost both CDKN2A and p53 were weakened and unable to compete with
other cells around them, preventing cancer from taking root. In contrast, if
cancer cells lose CDKN2A after the disease has had time to develop, it promotes
a more aggressive disease and worse outcomes for patients.
Himachal Pradesh Grants Full Salary to Doctors on Study LeaveIn a significant policy shift, the Himachal Pradesh government has announced that allopathic doctors pursuing postgraduate (PG) courses, senior residency, or Doctorate of Medicine (DM) programs will now receive their full salaries during their study leave. This decision, directed by Chief Minister Sukhvinder Singh Sukhu, aims to support medical professionals in advancing their education without financial constraints. Previously, a cabinet decision had reduced the salary for doctors on study leave to 40%, which deterred many from seeking further specialization due to financial concerns. The recent change reclassifies the period of advanced study as 'on duty,' ensuring that these medical practitioners continue to receive their full remuneration while enhancing their qualifications.Chief Minister Sukhu emphasized the importance of this initiative, stating that postgraduate medical students balance patient care responsibilities with their educational commitments, which is vital for both their professional growth and the state's healthcare system. By ensuring full pay during study leave, the government aims to support their dedication, enhancing both the quality of training for doctors and the healthcare services available to the public. This policy change is expected to lead to better patient outcomes and foster a more robust healthcare system, ultimately benefiting communities throughout Himachal Pradesh. The Himachal Medical Officers' Association has expressed gratitude for this decision, noting that the previous provision of only 40% salary was discouraging. The Chief Minister's swift and empathetic solution has significantly boosted morale among medical professionals. By investing in the professional development of its doctors, the Himachal Pradesh government aims to enhance the quality of medical services within the state, ensuring that residents have access to specialized and advanced healthcare without the need to seek treatment elsewhere.
By Auricle
February 20, 2025
CEE Kerala Initiates Stray Vacancy Round for PG Medical Admissions 2024The Commissioner of Entrance Examinations (CEE) Kerala has commenced the online stray vacancy allocation process for Postgraduate (PG) Medical Courses for the 2024 academic year. This initiative aims to fill vacant seats in Government Medical Colleges, the Regional Cancer Centre in Thiruvananthapuram, and self-financed medical colleges across the state. Eligible candidates listed in the Kerala State Merit list are invited to register their options through the official CEE website by 5:00 PM on February 20, 2025. The allotment will be based on the merit list and the preferences submitted online by the specified deadline. Candidates who receive an allotment are required to join the designated colleges and remit the necessary fees.The tentative schedule for the stray vacancy allotment is as follows:· Option Registration Period: February 18 to February 20, 2025, until 5:00 PM· Publication of Provisional Allotment (Phase I): February 21, 2025· Publication of Final Allotment (Phase I): February 22, 2025· Candidate Reporting to Allotted Colleges: February 23 to February 25, 2025, by 3:00 PM· College Authorities to Approve and Submit Admitted Candidates List: February 25, 2025, by 4:00 PM· Publication of Provisional Allotment (Phase II): February 25, 2025· Publication of Final Allotment (Phase II): February 26, 2025· Candidate Reporting to Allotted Colleges (Phase II): February 27 to February 28, 2025, by 4:00 PM· College Authorities to Approve and Submit Admitted Candidates List (Phase II): February 28, 2025Candidates must note that fresh option registration is mandatory for participation in the stray vacancy filling phase. An option registration fee is required, equivalent to the annual tuition fee for those opting only for Government Medical Colleges (including the Regional Cancer Centre) or ₹1,00,000 for those including self-financing colleges in their preferences. Candidates eligible for fee concessions, such as SC/ST/OE categories, will pay half of the specified amounts. The registration fee will be refunded to candidates who are allotted a seat and join the respective college; however, those who do not join the allotted seat will forfeit the registration fee as a penalty.It is crucial for candidates to understand that options registered in previous phases will not carry over to the stray vacancy phase; therefore, fresh registration of options is essential. Additionally, candidates who have already secured seats in earlier allotments and continue in those positions are not eligible to participate in this round. For detailed information and to access the option registration portal, candidates should visit the official CEE Kerala website.
By Auricle
February 20, 2025
Kashmiri MBBS Student Alleges Severe Ragging at Al-Ameen Medical CollegeKashmiri MBBS Student Alleges Severe Ragging at Al-Ameen Medical College In a deeply concerning incident, a second-year MBBS student from Kashmir, identified as Hamim, has reported severe ragging and assault by senior students at Al-Ameen Medical College in Vijayapura, Karnataka. The alleged abuse occurred following a cricket match altercation, escalating into physical and psychological harassment. According to the victim, the confrontation began when seniors from the 2019 batch objected to his presence near the cricket ground during a match between the 2019 and 2022 batches. Despite complying with initial requests to stay away, tensions escalated as seniors reportedly humiliated him, forcing him to perform an 'Al-Ameen salute,' sing, and dance. They allegedly attempted to coerce him into a car, implying further harm. When he resisted and tried to document the incident on his phone, their aggression intensified. Later that evening, a group of six to eight individuals allegedly stormed into Hamim's hostel room, subjected him to a brutal beating, and coerced him into recording an apology video under duress. They issued threats, warning him of dire consequences over the next four years and prohibiting him from participating in cricket during this period.In response to the complaint, the Vijayapura police have arrested five senior students: Mohammed Zainul (23), Sameer (24), Shaik Sawood (23), Mansoor Bhasha (24), and Muzzaffer alias Mujeeb Jamadar (23). They have been charged under relevant sections of the Bharatiya Nyaya Sanhita and the Karnataka Education Act, 1983, pertaining to assault and ragging. The Jammu and Kashmir Students Association (JKSA) has strongly condemned the incident, urging Karnataka Chief Minister Siddaramaiah to intervene and ensure justice for the victim. They emphasize the necessity for stringent anti-ragging measures to protect students, especially those from outside the state. This incident highlights the persistent issue of ragging in educational institutions, underscoring the urgent need for effective enforcement of anti-ragging policies to safeguard student welfare. #Ragging #StudentSafety #MedicalCollege #Karnataka #JusticeForHamimIn a deeply concerning incident, a second-year MBBS student from Kashmir, identified as Hamim, has reported severe ragging and assault by senior students at Al-Ameen Medical College in Vijayapura, Karnataka. The alleged abuse occurred following a cricket match altercation, escalating into physical and psychological harassment.According to the victim, the confrontation began when seniors from the 2019 batch objected to his presence near the cricket ground during a match between the 2019 and 2022 batches. Despite complying with initial requests to stay away, tensions escalated as seniors reportedly humiliated him, forcing him to perform an 'Al-Ameen salute,' sing, and dance. They allegedly attempted to coerce him into a car, implying further harm. When he resisted and tried to document the incident on his phone, their aggression intensified.Later that evening, a group of six to eight individuals allegedly stormed into Hamim's hostel room, subjected him to a brutal beating, and coerced him into recording an apology video under duress. They issued threats, warning him of dire consequences over the next four years and prohibiting him from participating in cricket during this period.In response to the complaint, the Vijayapura police have arrested five senior students: Mohammed Zainul (23), Sameer (24), Shaik Sawood (23), Mansoor Bhasha (24), and Muzzaffer alias Mujeeb Jamadar (23). They have been charged under relevant sections of the Bharatiya Nyaya Sanhita and the Karnataka Education Act, 1983, pertaining to assault and ragging.The Jammu and Kashmir Students Association (JKSA) has strongly condemned the incident, urging Karnataka Chief Minister Siddaramaiah to intervene and ensure justice for the victim. They emphasize the necessity for stringent anti-ragging measures to protect students, especially those from outside the state.This incident highlights the persistent issue of ragging in educational institutions, underscoring the urgent need for effective enforcement of anti-ragging policies to safeguard student welfare.#Ragging #StudentSafety #MedicalCollege #Karnataka #JusticeForHamimIn a deeply concerning incident, a second-year MBBS student from Kashmir, identified as Hamim, has reported severe ragging and assault by senior students at Al-Ameen Medical College in Vijayapura, Karnataka. The alleged abuse occurred following a cricket match altercation, escalating into physical and psychological harassment.According to the victim, the confrontation began when seniors from the 2019 batch objected to his presence near the cricket ground during a match between the 2019 and 2022 batches. Despite complying with initial requests to stay away, tensions escalated as seniors reportedly humiliated him, forcing him to perform an 'Al-Ameen salute,' sing, and dance. They allegedly attempted to coerce him into a car, implying further harm. When he resisted and tried to document the incident on his phone, their aggression intensified. Later that evening, a group of six to eight individuals allegedly stormed into Hamim's hostel room, subjected him to a brutal beating, and coerced him into recording an apology video under duress. They issued threats, warning him of dire consequences over the next four years and prohibiting him from participating in cricket during this period.In response to the complaint, the Vijayapura police have arrested five senior students: Mohammed Zainul (23), Sameer (24), Shaik Sawood (23), Mansoor Bhasha (24), and Muzzaffer alias Mujeeb Jamadar (23). They have been charged under relevant sections of the Bharatiya Nyaya Sanhita and the Karnataka Education Act, 1983, pertaining to assault and ragging.The Jammu and Kashmir Students Association (JKSA) has strongly condemned the incident, urging Karnataka Chief Minister Siddaramaiah to intervene and ensure justice for the victim. They emphasize the necessity for stringent anti-ragging measures to protect students, especially those from outside the state. This incident highlights the persistent issue of ragging in educational institutions, underscoring the urgent need for effective enforcement of anti-ragging policies to safeguard student welfare.
By Auricle
February 20, 2025
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